✅ “Flagyl 400 mg Tablets – Powerful Antibiotic for Infections & Parasites”

🔬 What is Flagyl 400 mg?

Flagyl 400 mg contains Metronidazole, a potent antimicrobial agent used to treat infections caused by anaerobic bacteria and protozoa. It is prescribed for a wide range of infections involving the gastrointestinal tract, genital tract, skin, and mouth.

Metronidazole is both antibacterial and antiprotozoal, making it highly effective against conditions like bacterial vaginosis, giardiasis, trichomoniasis, and amoebiasis.

⚙️ Mechanism of Action

Metronidazole works by entering microbial cells and disrupting DNA synthesis through formation of cytotoxic intermediates. This causes:

• Damage to microbial DNA
• Inhibition of nucleic acid synthesis
• Cell death in anaerobic bacteria and protozoa

💊 Indications (Uses)

Flagyl 400 mg is indicated for the treatment of:

• ✅ Bacterial vaginosis
• ✅ Trichomoniasis
• ✅ Giardiasis
• ✅ Amoebiasis (intestinal or liver abscess)
• ✅ Pelvic inflammatory disease (PID)
• ✅ Intra-abdominal infections (with other antibiotics)
• ✅ Dental infections & abscesses
• ✅ H. pylori eradication (in combination therapy)
• ✅ Clostridium difficile colitis (off-label)
• ✅ Post-surgical infections involving anaerobes

📋 Dosage and Administration

Dosage varies based on the infection type and medical condition. Always follow your doctor’s instructions.

Typical Dosage:

• Giardiasis / Amoebiasis: 400 mg three times daily for 5–10 days
• Trichomoniasis: 2 g as a single dose, or 400 mg twice daily for 7 days
• Bacterial infections (dental, GI, PID): 400–800 mg 2–3 times a day for 7–10 days
• Anaerobic infections: Often used with cephalosporins or penicillins

Administration Tips:

• Take with food or water to reduce stomach upset
• Avoid alcohol during treatment and 48 hours afterward

⚠️ Warnings and Precautions

• Strictly avoid alcohol – causes severe reactions (nausea, flushing, cramps)
• Use caution in hepatic impairment
• May cause metallic taste or dark-colored urine (harmless)
• Monitor for signs of peripheral neuropathy with long-term use

💢 Side Effects

Common:

• Nausea
• Diarrhea
• Metallic taste
• Abdominal discomfort
• Headache

Less Common:

• Dizziness
• Skin rash
• Dark urine
• Mouth sores

❗ Serious Adverse Effects (Rare):

• Seizures
• Encephalopathy
• Peripheral neuropathy
• Blood disorders (e.g., leukopenia, thrombocytopenia)

Serious effects are rare and typically occur with high doses or prolonged use.

🤰 Use in Pregnancy and Breastfeeding

• Pregnancy: Generally considered safe in second and third trimesters
• Breastfeeding: Caution advised – metronidazole is secreted in breast milk

🔄 Drug Interactions

Use with caution when taken with:

• Alcohol – may cause violent reactions
• Warfarin – increases anticoagulant effect (↑ bleeding risk)
• Disulfiram – can cause psychotic reactions
• Lithium – risk of toxicity may increase

🧊 Storage Instructions

• Store below 30°C (86°F)
• Keep tablets in a dry, cool place
• Protect from light and moisture
• Keep out of reach of children