“Fludrocortisone 100 mcg: Uses, Dosage, Side Effects & Warnings”

✅ What Is Fludrocortisone?

Fludrocortisone acetate is a synthetic corticosteroid with strong mineralocorticoid properties and mild glucocorticoid effects.

🔹 Primary Uses:

✅ Mechanism of Action

Fludrocortisone binds to mineralocorticoid receptors, primarily in the kidneys, to:

• Increase sodium reabsorption in the renal tubules
• Promote water retention
• Increase potassium and hydrogen ion excretion
• Help maintain blood pressure and blood volume

✅ Dosage & Administration

🔹Typical Adult Dose:

• 100 mcg (0.1 mg) orally once daily
• Dosage may be adjusted based on electrolyte levels, blood pressure, and clinical response

🔹Pediatric Use:

• Common in congenital adrenal hyperplasia; dose is weight-based and monitored closely

🔹Monitoring:

• Serum sodium, potassium, blood pressure, and weight should be regularly monitored
• Adjust dose based on signs of fluid overload or hypokalemia

✅  Side Effects

🔹Common Side Effects:

• Headache
• Swelling (edema)
• High blood pressure
• Dizziness
• Weight gain
• Muscle weakness

🔹Serious or Long-Term Effects:

• Hypokalemia (low potassium)
• Hypernatremia (high sodium)
• Fluid overload
• Heart failure or hypertension
• Gastrointestinal ulcers
• Glaucoma or cataracts (rare)

✅Warnings & Precautions

• Avoid abrupt discontinuation after long-term use—taper if stopping
• Use cautiously in patients with:
  • Heart disease or hypertension
  • Kidney impairment
  • Edema or fluid retention
  • Infections (can suppress immune response)

✅  Special Considerations

• Patients on fludrocortisone often also take hydrocortisone to replace glucocorticoid activity
• May require salt supplementation early in treatment or in high-temperature environments