brutinib 140 mg Capsules – Advanced Oral Treatment for Blood Cancer

🔹What is Ibrutinib 140 mg?

Ibrutinib 140 mg is an oral targeted therapy used to treat various blood cancers. It is classified as a Bruton’s tyrosine kinase (BTK) inhibitor, and works by blocking signals that help cancer cells grow and survive.

Ibrutinib is approved for the treatment of multiple B-cell malignancies and is often prescribed as a long-term daily medication for managing cancer progression.

🔹Approved Medical Uses

Cancer Type / Condition	Usage
Chronic Lymphocytic Leukemia (CLL)	Frontline or relapsed/refractory treatment
Small Lymphocytic Lymphoma (SLL)	Similar to CLL
Mantle Cell Lymphoma (MCL)	For relapsed/refractory cases
Waldenström’s Macroglobulinemia (WM)	Effective as monotherapy or in combination
Marginal Zone Lymphoma (MZL)	For relapsed cases after specific therapies
Chronic Graft-Versus-Host Disease (cGVHD)	Used when steroids fail in transplant patients

🔹Mechanism of Action

Ibrutinib irreversibly binds to and inhibits the BTK enzyme, a critical component of B-cell receptor signaling. By blocking this pathway, it:

• Prevents cancer cell proliferation
• Induces apoptosis (cell death) in malignant B cells
• Inhibits tumor cell migration and adhesion

🔹Dosage & Administration

Standard Adult Dosage	Condition Specific
Typically 420 mg once daily	CLL, SLL, WM
560 mg once daily	MCL, MZL
140–420 mg daily	Chronic GVHD, depending on patient response
140 mg Capsule	Often taken in multiples (e.g., 3×140 mg = 420 mg dose)

• Route: Oral, taken once daily
• Swallow whole: Do not crush, chew, or open capsules

📌 Dosage may vary based on other medications, kidney/liver function, and doctor guidance.

🔹Common Side Effects

Frequent	Serious
Diarrhea	Bleeding (including brain hemorrhage)
Fatigue	Irregular heart rhythm (atrial fibrillation)
Nausea	Infections (respiratory, urinary, etc.)
Rash or bruising	High blood pressure (hypertension)
Muscle/joint pain	Secondary cancers (rare)

🔹Warnings & Precautions

• Cardiac Risk: Can cause irregular heart rhythm; monitor ECG in high-risk patients
• Infection Risk: Increased risk of bacterial, fungal, and viral infections
• Liver Impairment: Dose adjustments may be needed

🔹Contraindications

• Known hypersensitivity to Ibrutinib
• Severe liver disease (dose modification required)
• Caution with pre-existing heart arrhythmias

🔹Storage Instructions

• Store at room temperature (20–25°C / 68–77°F)
• Protect from light and moisture
• Keep in original packaging
• Keep out of reach of children and pets