✅ “Norsunate 100 mg Tablets (Artesunate) – Effective Oral Treatment for Malaria”

🔬 What is Norsunate 100 mg?

Norsunate 100 mg is an oral antimalarial medication that contains Artesunate, a semi-synthetic derivative of artemisinin. It is used in the treatment of uncomplicated malaria, particularly due to Plasmodium falciparum, including multidrug-resistant strains.

⚙️ Mechanism of Action

Artesunate is converted in the body to its active metabolite, dihydroartemisinin (DHA). It works by:

• Producing free radicals that damage parasite proteins and membranes
• Rapidly reducing parasite load and symptoms of malaria

It is known for its rapid onset of action and is often used in initial or emergency malaria treatment.

💡 Indications (Uses)

Norsunate 100 mg is used for:

• Treatment of acute uncomplicated malaria due to Plasmodium falciparum
• Often part of ACT regimens, especially when used in combination with other longer-acting antimalarials
• Effective against chloroquine- and sulfadoxine-pyrimethamine-resistant malaria strains

Not intended for prevention (prophylaxis) of malaria.

📏 Dosage and Administration

✅ Typical Adult Dosing:

• Artesunate 100 mg taken once or twice daily, depending on the treatment protocol
• Often given for 3 days, followed by a partner drug like mefloquine, lumefantrine, or amodiaquine

Always follow a complete ACT regimen as advised by a healthcare provider.

📌 Dosing Notes:

• Must be taken with or after food to enhance absorption
• Ensure completion of the full course even if symptoms improve

🚫 Contraindications

• Hypersensitivity to artesunate or other artemisinin derivatives
• Patients with a history of severe allergic reactions to antimalarials

⚠️ Warnings and Precautions

• Not a stand-alone cure – should be part of a full treatment course with a partner drug
• Monitor for anemia or liver enzyme changes with prolonged use

💢 Possible Side Effects

Common:

• Headache
• Dizziness
• Nausea or vomiting
• Fatigue
• Mild abdominal pain

Less Common:

• Allergic skin reactions (rash, itching)
• Elevated liver enzymes
• Decreased white blood cell count (rare)

Severe (Rare):

• Hemolytic anemia
• Hypersensitivity reactions

Side effects are typically mild and temporary.

🔄 Drug Interactions

• • Other antimalarials (monitor for additive side effects)
  • Enzyme-inducing drugs like rifampicin or carbamazepine, which may reduce artesunate levels

📦 Storage Instructions

• Store at room temperature (below 25°C/77°F)
• Protect from moisture and direct sunlight
• Keep out of reach of children