“Paxobrook: Comprehensive Guide to the Generic COVID-19 Antiviral Treatment”

What is Paxobrook?

Paxobrook is a generic antiviral medication developed by Healing Pharma India Pvt. Ltd., formulated to treat mild-to-moderate COVID-19 infections. It combines two active ingredients: Nirmatrelvir (150 mg) and Ritonavir (100 mg). This combination mirrors the composition of Paxlovid, an antiviral therapy developed by Pfizer.

🧬 Composition and Mechanism of Action

• Nirmatrelvir: This component inhibits the SARS-CoV-2 main protease (Mpro), an enzyme essential for viral replication. By blocking this protease, Nirmatrelvir prevents the virus from multiplying within the body.
• Ritonavir: Originally used in HIV treatment, Ritonavir in this combination acts as a pharmacokinetic enhancer. It inhibits the CYP3A enzyme, slowing the metabolism of Nirmatrelvir, thereby increasing its concentration and effectiveness in the body.

💊 Dosage and Administration

The standard regimen involves taking 300 mg of Nirmatrelvir (two 150 mg tablets) and 100 mg of Ritonavir (one 100 mg tablet) twice daily for five days. Each combipack contains 30 tablets: 20 tablets of Nirmatrelvir and 10 tablets of Ritonavir, sufficient for the five-day course.

✅ Indications and Eligibility

• Adults and pediatric patients aged 12 years and older
• Who have tested positive for SARS-CoV-2

It is essential to consult a healthcare provider to determine eligibility and appropriateness of treatment.

⚠️ Precautions and Contraindications

• Drug Interactions: Ritonavir is a potent inhibitor of the CYP3A enzyme, which can lead to significant interactions with other medications metabolized by this pathway. Patients should inform their healthcare provider of all medications they are taking.
• Contraindications: Paxobrook should not be used in patients with known hypersensitivity to Nirmatrelvir, Ritonavir, or any of its components.
•  Renal and Hepatic Impairment: Dose adjustments may be necessary for patients with moderate renal impairment.

💰 Pricing

The price of Paxobrook can vary depending on the supplier and region.

📦 Storage Instructions

Store Paxobrook below 25°C in a dry place, away from direct sunlight. Keep the medication out of reach of children.