✅ Pirfenex 400 mg – Trusted Antifibrotic for Pulmonary Fibrosis Treatment

🔍 What is Pirfenex 400 mg?

Pirfenex 400 mg contains Pirfenidone, a novel antifibrotic and anti-inflammatory agent used primarily to treat Idiopathic Pulmonary Fibrosis (IPF)—a chronic, progressive, and ultimately fatal lung disease characterized by scarring of lung tissues.

Pirfenidone helps slow down the progression of the disease by reducing lung fibrosis (scarring) and inflammation, thereby improving the quality of life and preserving lung function.

✅ Uses of Pirfenex 400 mg

Pirfenex 400 mg is prescribed for:

• Idiopathic Pulmonary Fibrosis (IPF) – To slow disease progression
• Off-label use (under research): Other fibrotic disorders (e.g., scleroderma, liver fibrosis)

⚠️ Use only under specialist supervision for non-IPF conditions.

💊 Dosage and Administration

Pirfenidone dosing is usually gradual to minimize side effects:

• Week 1: 267 mg (1 tablet) three times daily
• Week 2: 534 mg (2 tablets) three times daily
• Week 3 onward (maintenance dose): 801 mg (3 tablets) three times daily = 2403 mg/day

Pirfenex 400 mg tablets are often used in combination (e.g., 2 × 400 mg = 800 mg) to meet dosing needs.

Instructions:

• Take with food to reduce nausea.
• Swallow tablets whole with water.
• Do not skip doses or stop suddenly without medical advice.

⚙️ How Pirfenex Works

Pirfenidone works by modulating TGF-β and TNF-α—two proteins involved in inflammation and fibrosis. It reduces fibroblast proliferation, cytokine production, and collagen synthesis, helping to slow the progression of lung scarring in IPF.

⚠️ Precautions and Warnings

• Liver Monitoring: Regular liver function tests required.
• Photosensitivity: Avoid sunlight or wear protective clothing and SPF.
• Avoid Alcohol: May increase liver toxicity risk.
• Not recommended for:
  • Severe liver or kidney disease
  • Children (safety not established)
  • Pregnancy or breastfeeding unless advised by a specialist

💢 Side Effects of Pirfenex 400 mg

🔔 Inform your doctor if you notice yellowing of the skin, dark urine, or persistent nausea.

🔄 Drug Interactions

Avoid use with:

• Ciprofloxacin or fluvoxamine – Increases pirfenidone levels
• Smoking – Reduces drug efficacy
• Strong CYP1A2 inhibitors – May increase side effects

Always inform your doctor of all medications or supplements you are using.

📦 Storage Instructions

• Store at room temperature (15–30°C)
• Protect from moisture, heat, and light
• Keep away from children