✅ “Zycolchin 0.5 mg Tablets – Trusted Colchicine Treatment for Gout & Inflammatory Conditions”

🔬 What is Zycolchin 0.5 mg?

Zycolchin 0.5 mg is an oral tablet formulation containing Colchicine, a medication primarily used to prevent and treat gout attacks. It also has applications in familial Mediterranean fever (FMF) and pericarditis. Colchicine works by reducing inflammation and pain caused by uric acid crystal buildup in joints.

⚙️ How Zycolchin Works

Colchicine interferes with the migration of white blood cells to the sites of inflammation caused by uric acid crystals. This:

• Reduces inflammation
• Alleviates pain and swelling in joints
• Prevents recurrent gout attacks
• Modifies the body’s inflammatory response in FMF and pericarditis

💊 Indications (Uses)

Zycolchin 0.5 mg is indicated for:

• ✅ Acute gout attacks
• ✅ Prevention of recurrent gout flares
• ✅ Familial Mediterranean Fever (FMF)
• ✅ Pericarditis (inflammation of the heart’s lining) (off-label)
• ✅ Behçet’s disease (off-label)

📋 Dosage and Administration

Always take Zycolchin as prescribed by a healthcare provider.

Acute Gout Flare:

• Initial dose: 1–1.2 mg (e.g., 2 tablets) at the first sign of an attack
• Followed by 0.5–0.6 mg every hour or 0.5 mg every 2 hours, up to a maximum total of 6 mg per course

Gout Prophylaxis:

• 0.5 mg once or twice daily

Familial Mediterranean Fever (FMF):

• 1–2 mg daily, in divided doses

Note: Dose adjustments are required in elderly patients, those with kidney/liver disease, or when used with other medications.

⚠️ Warnings and Precautions

• Use with caution in renal or hepatic impairment
• Avoid grapefruit juice – may increase toxicity
• Do not exceed the recommended dose – risk of serious toxicity
• Inform your doctor if you are taking CYP3A4 inhibitors or P-gp inhibitors (like clarithromycin, verapamil)
• Caution in elderly patients due to reduced metabolism

💢 Side Effects

Common:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain

Less Common:

• Muscle pain or weakness
• Peripheral neuropathy
• Blood disorders (low white blood cells, anemia)
• Hair thinning

Gastrointestinal side effects are most common and often dose-related.

❗ Serious Adverse Reactions (Rare but Severe)

• Severe muscle damage (rhabdomyolysis)
• Bone marrow suppression
• Liver or kidney toxicity
• Death in cases of overdose or drug interaction

🤰 Use in Pregnancy and Breastfeeding

• Pregnancy Category C – Use only if benefits outweigh risks
• Present in breast milk – avoid during breastfeeding unless prescribed with caution

🔄 Drug Interactions

Colchicine is metabolized by the CYP3A4 enzyme and P-glycoprotein. Use caution with:

• Macrolide antibiotics (clarithromycin, erythromycin)
• Antifungals (ketoconazole, itraconazole)
• Statins (simvastatin, atorvastatin – ↑ risk of muscle damage)
• HIV protease inhibitors
• Grapefruit juice

🧊 Storage Instructions

• Store below 25°C (77°F)
• Keep in a dry, cool place
• Keep out of reach of children