Ceritinib 150 mg (Zykadia): Complete Guide to Uses, Dosage, Side Effects & Safety

✅ What is Ceritinib 150 mg Used For?

Ceritinib 150 mg is a targeted therapy primarily used for the treatment of ALK-positive non-small cell lung cancer (NSCLC). It is effective in patients whose cancer cells have a mutation in the ALK gene, which drives tumor growth.

🔄 Drug Interactions

Ceritinib interacts with several other drugs:

1. CYP3A Inhibitors:
   • Ketoconazole, ritonavir, and other strong CYP3A inhibitors may increase Ceritinib levels, increasing the risk of side effects.
2. CYP3A Inducers:
   • Drugs like rifampin, carbamazepine, and phenytoin may reduce Ceritinib levels and its effectiveness.
3. Acid-Reducing Agents:
   • Proton pump inhibitors (PPIs) and H2 blockers can decrease the absorption of Ceritinib.

📋 Side Effects

Common Side Effects:

• Diarrhea (most common)
• Nausea and vomiting
• Fatigue
• Abdominal pain
• Decreased appetite
• Liver enzyme abnormalities (elevated ALT, AST)
• Visual disturbances (blurred vision)

Serious Side Effects:

• Pneumonitis (lung inflammation)
• QT prolongation (leading to arrhythmias)
• Hepatotoxicity (severe liver damage)
• Severe diarrhea and dehydration
• Ocular toxicity (visual changes)

🧊 Storage Instructions

• Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Keep in the original packaging and protect from moisture and light.
• Keep out of reach of children.

🧾 Patient Counseling Information

• Take Ceritinib with food to enhance absorption.
• Monitor for signs of liver problems (e.g., jaundice) and inform your healthcare provider if you experience any unusual symptoms.
• Stay hydrated to help manage gastrointestinal side effects like diarrhea.
• Use effective contraception during treatment and for at least 2 weeks after stopping Ceritinib.
• Report any signs of lung inflammation, vision problems, or heart rhythm issues immediately to your doctor.