✅ Imiquimod Sachet 5% Cream: Complete Guide to Uses, Dosage, Side Effects & Application Tips

✅ Indications (Uses)

Imiquimod is used to stimulate the immune system to fight abnormal skin growths and certain viral infections. It is commonly prescribed for:

🔹 1. Actinic Keratosis (AK):

• Rough, scaly patches caused by sun damage
• Used on the face or scalp in adults

🔹 2. Superficial Basal Cell Carcinoma (sBCC):

• A type of non-melanoma skin cancer
• Used when surgery is not appropriate

🔹 3. External Genital and Perianal Warts:

• Caused by human papillomavirus (HPV)
• Used in adults for warts on the outside of the genital/anal area

Not for use inside the vagina, anus, or urethra.

⚙️ Mechanism of Action

Imiquimod acts as an immune response modifier by:

• Binding to toll-like receptors (TLR7) on immune cells
• Stimulating the release of cytokines, particularly interferon-α, TNF-α, and interleukins
• Activating innate and cell-mediated immunity
• Helps the body recognize and destroy abnormal or virus-infected skin cells

🕒 Dosage & Application

Dosage and duration depend on the condition being treated. Always follow your healthcare provider’s instructions.

✅ General Application Instructions:

1. Apply at bedtime to clean, dry skin.
2. Use a thin layer of cream, only on affected area.
3. Do not cover with bandages unless instructed.
4. Wash hands before and after application.
5. Leave cream on the skin for 6–10 hours, then wash off with mild soap and water.

⚠️ Side Effects

Common Local Reactions:

• Redness
• Swelling
• Itching or burning
• Scabbing or flaking
• Erosions or ulcerations (temporary)

Systemic Effects (Rare):

• Fatigue
• Flu-like symptoms (fever, body aches)
• Headache
• Nausea

Most side effects are local and self-limiting, but contact a doctor if reactions become severe.

🛑 Warnings & Precautions

• For external use only – not to be applied internally or on broken skin
• Avoid use near eyes, lips, and nostrils
• Do not apply to open wounds or infected skin
• May cause temporary hypopigmentation or hyperpigmentation
• Patients with autoimmune disorders should consult a doctor before use
• Avoid sun exposure or use sunscreen during treatment

🔄 Drug Interactions

• No significant systemic drug interactions due to minimal absorption
• Avoid concurrent use with topical corticosteroids, which may reduce Imiquimod’s effectiveness

📦 Storage Instructions

• Store below 25°C (77°F)
• Do not refrigerate or freeze
• Single-use sachets – discard after one application, even if cream remains
• Keep out of reach of children